Functionalized Magnetic Materials for biomedicine and nanotechnology center

Main research fields of the Laboratory of Immunology and cellular biotechnology

General information
  1. Mechanisms of metabolic abnormalities in insulin resistance;

  2. Cellular and molecular genetic mechanisms regulating the activation process, differentiation and self-immune memory;

  3. Development of innovative ways of diagnosing the risk of endometriosis by polymerase chain reaction in real time;

  4. Working out scientific and technological potential to create tissue-engineered constructs based biocomposite materials and cultured cells in vitro;

  5. The study of the potential therapeutic properties of multipotent mesenchymal stromal cells of post-natal tissues of animals with a view to their application in regenerative veterinary medicine.

  1. Multimodal microplate reader Mithras Research II,

  2. Aggregometer 490-2D optical, 2-channel, including DESTEN computer set. HRONOPAR Collagen,

  3. Microscope Akiostar Plus,

  4. SKH4 Olympus inverted microscope,

  5. CO2 Incubator MCO-15AS, Sanyo,

  6. High Water purification system Simplicity UV, Millipore,

  7. Drying ovens MOV-212F, Sanyo,

  8. Hemostasis Analyzer Coagulometer ACL 7000

  9. Automatic Biochemical Analyzer CA-180,

  10. Flow digital fluorometer EasyCyte Plus Base System, Guava Technologies,

  11. Flow cytofluorometer MACSQuant Analyzer,

  12. Automatic immunomagnetic cell sorter AutoMACS Pro starter kit,

  13. Device for biomarkers diagnosis of Bio-Plex System with the automated Bio-Plex Pro Wash Station plate washer system,

  14. SAS-1 Plus / SAS-2 230 Automated Protein Electrophoresis System, V-HELENA BioScienses Europe,

  15. Analyzer LightCycler 480-II for the PCR analysis in real time: a fuser 96-well plate modification,

  16. LightCycler 480 analyzer for PCR testing in real time: a fuser 384-well plate modification,

  17. LNP40 Generator of liquid nitrogen ,

  18. System for living cells culture monitoring Cell-lQ v.2 with accessories,

  19. Research biological fluorescent microscope,

  20. Real-time cell analyzer, assembled / RTCA xCELLigence DP bundle (complete with plates E-Plate-hole.)

  21. Automated Immunoenzymometric Analyzer "Lazurite" (Lapis) with accessories, "Dynex Technologies"

Research Team
  1. Литвинова Л.С.Litvinova Larisa, Dr. of Medicine, Head of the Laboratory,,
  2. Shupletsova Valeria, PhD in Biology,
  3. Kirienkova Elena, PhD. in Medicine,
  4. Aksenova Natalia, PhD. in Biology,
  5. Zima Anastasia, Dr. of Medicine,
  6. Vasilenko Maria,
  7. Dunets Natalia, PhD in Biology,
  8. Skuratovskaya Darya,
  9. Haziahmatova Olga, PhD. in Biology,
  10. Yurova Christine, PhD. in Medicine,

  1. Changes of immune parameters during T-cells vaccination in patients with rheumatoid arthriris / Ivanova I.P., Seledzova G.V., Mamaev S.V., Litvinova L.S., Lopatnikova Yu.A., Sennikov S.V., Seledzov V.I. // Russian Journal of Immunology. – 2011. V. 5 (14). №3-4. P. 341-349.

  2. The impact of age and gender on the indicators of coagulator and vascular thrombocyte hemostasis in patients with II type diabetes mellitus / Kondratieva E.I., Suhanova G.A., Litvinova L.S., Kirienkova E.V., Kretova E.I., Zatolokln P.A. // Klinichescheskaya Laboratornaya Diagnostika – 2011. №8. P. 41-43.

  3. The impact of surgical correction of obesity (laparoscopic gastro-bypass surgery) under metabolic syndrome on the biochemical blood indicators / Kiriyenkova Y.V., Litvinova L.S., Seledzov V.I., Zalotkin P.A., Aksenova N.N. // Klinicheskaia laboratornaia diagnostika. - 2012. V. 12. P. 3-5.

  4. Eosinophil: A modern concept of the kinetics, structure, and function / Kolobovnikova Yu.V., Urazova O.I., Novitsky V.V., Litvinova L.S., Chumakova S.P. // Gematologiya i Transfusiologiya. – 2012. V. 57(1). P. 30-36.

  5. Dose-response effect of steroid hormones on the Gfi1 and U2afil4 gene expression in T lymphocytes at different stages of differentiation / Gutsol A.A.Sokhonevich N.A., Seledtsov V.I., Litvinova L.S. // Molecular Biology. - 2013. V. 47(4). P. 572–580.

  6. Dexamethasone effects on activation and proliferation of immune memory T cells / Gutsol A.A.Sokhonevich N.A., Seledtsov V.I., Litvinova L.S. // Bulletin of Experimental Biology and Medicine. - 2013. V. 155(4). P. 474-476.

  7. The Content of p53 Protein in Tumor Cells by the Action of a Selective Inhibitor of Hsp27 Chaperone in vitro / Kaigorodova E.V., Litvinova L.S., Konovalova E. V., Klimova М.V., Tashireva L.A., Nosareva O. L., Novitskiy V. V. // International Journal of Biology. - 2013. Vol. 5, №3. – P. 13-18.

  8. Features of cytokine-producing ability of peripheral blood mononuclear cells in the metabolic syndrome / Litvinova L.S.Kirienkova E.V., Gazatova N.D., Zatolokin P.A., Vasilenko М.А., Aksenova N.N., Simbirtsev A.S.  // Cytokines and inflammation. – 2013. №3. P. 62-66.

  9. Effects of steroid hormones upon Th1/Th2 cytokine production by CD45RO+ T cells / Gutsol A.A.Litvinova L.S. // Medical Immunology. – 2013. V. 15(3). P. 263-268.

  10. The influence of immunoregulatory cytokines IL-2, IL-7, and IL-15 upon activation, proliferation, and apoptosis of immune memory T-cells in vitro / Litvinova L.S., Sokhonevich N.A., Gutsol A.A., Kofanova K.A. // Cell and Tissue Biology. - 2013. V. 7(6). P. 539-544.

  11. Study of the nanostructure and cytotoxicity of ZrO2 and Al2O3 ceramic implants / Litvinova L., Shupletsova V., Leitsin V., Shusharina N., Botsman S., Kulkov S., Vasyliev R., Zubov D. // Regenerative Medicine. – 2013. V. 8(6s). P. 191–192.

  12. Human endometrial stromal cells: in vitro biological properties under conventional and low oxygen cell culture conditions / Vasyliev R., Zubov D., Rodnichenko A., Litvinova L., Korop Z., Sednev O., Kurmyshov A. // Regenerative Medicine. – 2013. V. 8 (6s). P. 176–177.

  13. Pathogenesis of Insulin Resistance in Metabolic Obesity / Litvinova L.S., Kirienkova E.V., Mazunin I.O., Vasilenko M.A., Fattakhov N.S. // Biochemistry. – 2014. V. 8(3). P. 192-202.

  14. Тhe effects of testosterone and β-estradiol on activation of lymphocytes associated with IL-2 production and expression / Gutsol A.A.Sokhonevich N.A., Kofanova K.A., Litvinova L.S. // Cell and Tissue Biology. – 2014. V. 8(6). P. 473–477.

  15. Evaluating the Number of Mitochondrial DNA Copies in Leukocytes and Adipocytes from Metabolic Syndrome Patients: Pilot Study / Mozhei O.I., Zatolokin P.A., Vasilenko M.A., Litvinova L.S., Kirienkova E.V., Mazunin I.O. // Molecular Biology. – 2014. V. 48(4). P. 589–592.

  16. Role of adiponectin and pro-inflammatory gene expression in adipose tissue chronic inflammation in women with metabolic syndrome [Electronic resource] / Litvinova L.S., Atochin D.N., Vasilenko M.A., Fattakhov N.S., Zatolokin P.A., Kirienkova E.V. // Diabetology & Metabolic Syndrome. – 2014. - Mode of access:

  17. Porosity and biocompatibility study of ceramic implants based on ZrO2 and Al2O3 / Litvinova L., Shupletsova V., Leitsin V., Vasyliev R., Zubov D., Buyakov A., Kulkov S. // Conference Collection. International Conference on Physical Mesomechanics of Multilevel Systems 2014. – 2014. V. 1623. P. 347-350.

  18. The role of nitric oxide synthases in the development of mitochondrial dysfunction in metabolic syndrome [Electronic resource]   / Litvinova L.S., Atochin D.N., Fattakhov N.S., Vasilenko M.A., Zatolokin P.A., Kirienkova E.V. // Front Physiol. – 2015. - Mode of access:

  19. Cytokine-Mediated Regulation of Expression of Gfi1 and U2afll4 Genes by Activated T-Cells with Various Differentiation Status In Vitro / Yurova K.A., Sokhonevich N.A., Khaziakhmatova O.G., Litvinova L.S. // Biomedical Chemistry. – 2015. V. 9(2). P. 165-172.

  20. Effects of Immunoregulatory Cytokines (IL-2, IL-7, and IL-15) on Expression of Gfi 1 and U2afl l4 Genes in T Cells at Different Stages of Differentiation / Sokhonevich N.A., Yurova K.A., Gutsol A.A., Khaziakhmatova O.G., Mazunin I.O., Litvinova L.S. // Bulletin of Experimental Biology and Medicine. - 2015. - Vol. 159, No. 2. P. 236 – 239.

  21. Dose-Dependent Effects of Dexamethasone on Functional Activity of T-Lymphocytes with Different Grades of Differentiation / Gutsol A.A., Sokhonevich N.A., Yurova K.A., Khaziakhmatova O.G., Shupletsova V.V., Litvinova L.S. // Molecular Biology. - 2015. Vol. 49, No. 1. P. 130–137.

  22. Phenotypic characterization and functional features of memory T- and B-cells / Sokhonevich N.A., Khaziakhmatova O.G., Yurova K.A., Shupletsova V.V., Litvinova L.S. // Tsitologiia. - 2015. Vol. 57 (5). P. 311-318.

  23. Insulin resistance pathogenesis in metabolic obesity / Litvinova L.S., Kirienkova E.V., Mazunin I.O., Vasilenko M.A., Fattakhov N.S.  // Biomedical Chemistry. – 2015. V. 61(1). P. 70-82.

  24. Nitric oxide and mitochondria in metabolic syndrome / Litvinova L., Atochin D., Fattakhov N., Vasilenko M., Zatolokin P., Kirienkova E. // Frontiers in Physiology, 2015. – Vol. 6. – Mode of access:

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